SARMs & Related Compounds
Stenabolic
SR-9009 · Rev-erbα agonist
What it is
Stenabolic (SR-9009) is NOT a SARM — it's a synthetic Rev-erbα nuclear receptor agonist developed for metabolic disease. It modulates circadian rhythm and energy metabolism, increasing fat oxidation and endurance. Pre-clinical data is strong; no human studies. Niche compound; poorly bioavailable.
How it works
Rev-erbα is a circadian rhythm regulator. Agonism improves mitochondrial function, increases fatty acid oxidation, and shifts energy metabolism. Animal studies show improved endurance, reduced obesity, and enhanced metabolic rate. Poor oral bioavailability means it's mostly a pre-clinical compound.
Benefits
- Increased fat oxidation (animal data)
- Endurance improvement (animal data)
- Possible metabolic rate elevation
- Circadian rhythm optimization (theoretical)
Timeline
- Week 1–2
- Energy/alertness increase; appetite suppression.
- Week 2–6
- Fat loss acceleration; endurance improvements.
- Week 6+
- Plateau; unclear optimal cycle length (no human data).
Dosing & titration
Reported dose10–40 mg orally daily (highly variable absorption)
Cycle length8–12 weeks (not studied; extrapolated from animal models)
When to titrate upStart 10 mg, increase to 20–40 mg based on tolerance.
TimingCircadian agonist — dose in morning for best effect.
Side effects & risks
- Insomnia (if dosed too late, due to circadian activation)
- GI upset in some users
- Lethargy / lack of appetite (more common than stimulation)
- No androgen suppression (unlike SARMs)
- Long-term safety unknown (no human studies)
No human safety data. All evidence is from animal models. Bioavailability is poor and highly variable. Optimal dose, duration, and safety profile unknown. Not banned in sports (but check current rules). Experimental compound — proceed with caution.
Typical price
$50–$100/moResearch suppliers; quality variable.
Studies
- Solt LA et al. Regulation of circadian behaviour and metabolism by synthetic Rev-erb agonists — Foundational animal pharmacology. PubMedNature, 2012
- Search PubMed for SR-9009 / stenabolic — PubMed searchLive PubMed search
Educational reference only. Not medical advice. Not FDA-approved. No human trials completed.