Immune & Anti-Inflammatory
Lactoferrin
milk-derived iron-binding glycoprotein
What it is
Lactoferrin is a multifunctional iron-binding glycoprotein found naturally in colostrum, milk, tears, saliva, and other secretions. Has antimicrobial, anti-inflammatory, and immune-modulating effects. Available as an oral supplement (food-grade, GRAS designation by FDA).
How it works
Several mechanisms: (1) sequesters iron from pathogens, starving them of an essential nutrient; (2) directly binds and disrupts microbial membranes; (3) modulates immune cell activity; (4) supports gut barrier function and microbiome.
Benefits
- Antimicrobial activity (bacteria, viruses, fungi)
- Gut barrier and microbiome support
- Immune modulation
- Anti-inflammatory effects
- Iron metabolism support (in iron deficiency)
- Some evidence for chronic infection support
Timeline
- Week 1–2
- Gut symptom improvements possible.
- Week 4–8
- Cumulative immune effects.
Dosing & titration
Standard dose250–1000 mg orally daily
TimingEmpty stomach for systemic effect; with food for gut effects
Cycle lengthCan be daily long-term
When to titrate upHigher doses for chronic conditions; most users do well at 500 mg/day.
Side effects & risks
- Generally very well tolerated (food-grade)
- Rare: GI upset
- Rare: allergic reactions in dairy-allergic individuals
Available without prescription — one of the few "peptides" you can buy at any health store.
Typical price
$30–$80/moCapsules at health stores or online.
Studies
- Wang B et al. Lactoferrin: Structure, function, denaturation and digestion — Comprehensive review. PubMedCritical Reviews in Food Science and Nutrition, 2017
- Search PubMed for lactoferrin — PubMed searchLive PubMed search
Educational reference only. Not medical advice.