Healing & Anti-Inflammatory
KPV
Lysine-Proline-Valine · α-MSH C-terminal fragment
What it is
KPV is a tripeptide (just three amino acids) found at the C-terminus of α-MSH. It has potent anti-inflammatory and antimicrobial effects without the pigmentation effects of full α-MSH. Mostly used as an oral capsule for gut/intestinal inflammation.
How it works
Inhibits NF-κB signaling, reducing inflammatory cytokines. Has direct antimicrobial activity against bacteria, fungi, and yeast. Particularly active in the gut and on skin.
Benefits
- Gut inflammation reduction (IBD, IBS, leaky gut)
- Anti-inflammatory effects systemically
- Skin inflammation (eczema, psoriasis)
- Antimicrobial activity
- Wound healing support
Timeline
- Week 1–2
- Reduced GI symptoms in users with gut issues.
- Week 4
- More noticeable inflammation reduction.
- Week 6–8
- End of typical cycle.
Dosing & titration
Oral dose200–500 mcg, 1–2x daily
SubQ dose200–400 mcg daily
Cycle length4–8 weeks
When to titrate upIf oral form produces no change after 2 weeks, switch to subQ for better bioavailability.
Side effects & risks
- Generally very well tolerated
- Rare: mild GI upset
- Very few reported side effects in literature
Often paired with BPC-157 for gut healing protocols.
Typical price
$60–$100/moOral capsules or vial from a 503A compounding pharmacy.
Studies
- Brzoska T et al. α-MSH-derived tripeptide KPV: anti-inflammatory and immunomodulatory properties — Mechanism review. PubMedEndocrine Reviews, 2008
- Search PubMed for KPV — PubMed searchLive PubMed search
Educational reference only. Not medical advice.