SARMs & Related Compounds

Cardarine

GW-501516 · Endurobol · PPARδ agonist

dangernicheoral capsule / liquid

What it is

Cardarine (GW-501516) is NOT a SARM — it's a PPARδ (peroxisome proliferator-activated receptor delta) agonist developed for metabolic disease. It was dropped from development due to universal cancer in animal models at all doses. Extreme endurance and fat loss, but development halted. Effectively unavailable and extremely dangerous.

How it works

Activates PPARδ receptors in muscle and fat tissue, increasing fatty acid oxidation, mitochondrial biogenesis, and endurance capacity. Dramatically improves insulin sensitivity and shifts energy metabolism toward fat utilization. Cancer observed in multiple tissue types in preclinical studies.

Benefits

Extreme endurance (2x+ VO2 max improvement in animal models)
Rapid fat loss
Improved insulin sensitivity
Possible neuroprotection (never studied in humans)

Timeline

Week 1–3: Fatigue tolerance; endurance spike.
Week 4–8: Fat loss acceleration; muscle preservation.
Week 8+: Cancer risk accrues with duration — development terminated.

Dosing & titration

Reported dose (DO NOT USE)10–20 mg orally daily

Cycle lengthNot applicable — development halted for safety

WARNINGDO NOT USE. Cancer observed at all doses in animal models. No safe threshold identified.

Side effects & risks

CANCER — carcinogenic in all tissues tested, all doses
Development halted by sponsor (GSK) in 2007
No human safety data; only preclinical (animal) toxicity
Banned in all sports
Illegal in most countries

DO NOT USE. Development was stopped due to cancer risk observed universally in animal studies. Zero human safety data. Not approved by any regulatory body. Illegal in most countries. Any supplier claiming safety is lying. Effective fat loss does not justify carcinogenicity.

Typical price

N/A — illegally unavailableNot recommended at any price.

Studies

Lutz K et al. Development of PPARδ agonists. GSK terminated GW-501516 development — Carcinogenicity led to halt of all human trials. PubMedSearch PubMed for GW-501516 cancer

Educational reference only. Not medical advice. Not FDA-approved. DO NOT USE — carcinogenic.