SARMs & Related Compounds
Andarine
S-4 · GTx-007
What it is
Andarine (S-4) is one of the original SARMs — an early GTx Inc. compound. It's known for producing a "dry" lean look during cuts, but is famous for the yellow vision tint side effect. Less popular than newer SARMs, but cheap and effective for body recomposition.
How it works
Selective androgen receptor binding favoring muscle and bone. Slightly less anabolic than Ostarine but produces a notably "harder" look due to its effect on body water and androgen receptor activity in fat tissue.
Benefits
- Lean, dry look during cuts
- Hard muscle aesthetic (vascularity)
- Bone density support
- Mild fat loss
- Strength preservation in caloric deficit
Timeline
- Week 1–2
- Strength gains; visible "tightening."
- Week 4–6
- Visible recomposition, especially leaner look.
- Week 8
- End of typical cycle; PCT required.
Dosing & titration
Standard dose25–50 mg orally daily, split in 2 doses
Cycle length6–8 weeks ON, 4–6 weeks OFF (with PCT)
TimingHalf-life is short (~4 hours) so split dosing is standard
When to titrate upAbove 50 mg/day, vision side effects increase dramatically. Most users stay at 25–50 mg.
Side effects & risks
- Yellow tint to vision (binds to ocular androgen receptors) — usually reversible after cycle
- Difficulty with night vision
- Testosterone suppression
- HDL reduction
- Liver enzyme changes
Vision side effect is real. If yellow tint appears, lower dose or stop cycle. Almost always reverses post-cycle but document with eye exam if persistent.
Typical price
$50–$100/moFrom research suppliers.
Studies
- Search PubMed for andarine / S-4 — PubMed searchLive PubMed search
- Gao W, Dalton JT. Expanding the therapeutic use of androgens via SARMs — Class review including S-4. PubMedDrug Discovery Today, 2007
Educational reference only. Not medical advice. Not FDA-approved.